• Promotes methylation
  • Decreases dangerous levels of homocysteine
  • Lowers the risk of cardiovascular disease
  • Protects against damaged blood vessels

MaxMethyl provides nutrients that help in tissue formation, the formation of red blood cells, the metabolism of carbohydrates, fats and proteins and which are factors in the maintenance of good health.

90 Vegi-Caps 

Serving Size:                          1 Capsule

  • Trimethylglycine…………………………………………….. 500 mg
  • (betaine anhydrous)
  • Folate (calcium L-5-MTHF) 267 mcg Vitamin B6 (pyridoxal-5-phosphate)……………………………………………………………………….. 17mg
  • Vitamin B12 (methylcobalamin)……………………… 216 mcg

Key Features:

  • Potent methylating agents
  • Bioavailable forms of ingredients

Suggested Use: Take 1 capsule three times per day with or without food, or as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner prior to use if you have liver or cardiovascular disease.

Pregnancy / Nursing: Consult a health care practitioner

Source: Pharmaceutical synthesis

Main Indications:

  • Homocysteine
  • Methylation
  • Cellular maintenance
  • Cardiovascular disease
  • Hypertension

Complementary Products: Advanced Cardiac Support, Advanced B Complex, CoQ Plus

A Dangerous Amino Acid

Homocysteine is a byproduct of an important metabolic process called the methylation cycle. It is a derivative of the essential amino acid methionine, and can be recycled into various useful products by the addition of methyl groups. Unfortunately, homocysteine is toxic at high levels. When it accumulates, it can damage blood vessels and impede collagen formation, increasing the risk of cardiovascular disease.

Homocysteine Control

In order to recycle homocysteine into useful products and prevent it from accumulating, other participants in the methylation cycle are required. The main cofactors are Vitamin B6, Vitamin B12 and folate. The process also requires methyl donors, such as trimethylglycine which is the most effective homocysteine lowering substance known. Unfortunately, most people do not get enough of these nutrients in their diets.

Protect your Heart

MaxMethyl is formulated to include all the cofactors and methyl donors needed to convert homocysteine into useful amino acids, thereby helping to reduce the risk of heart disease.

Protect yourself against elevated homocysteine levels

Homocysteine is a toxic amino acid. It is naturally produced in the body as a byproduct of several metabolic pathways, such as the metabolism of the amino acid methionine to produce essential nucleic acids, fats and high-energy bonds. When methionine loses a methyl group, homocysteine is produced. If homocysteine levels increase, blood vessels are damaged and collagen formation is impeded. There are two pathways in the human body that can lead to the elimination of homocysteine: it can be methylated to methionine or condensed into cysteine. The former process requires folate and vitamin B12, while the latter is vitamin B6 dependant.

Why is Homocysteine harmful?

Elevated blood levels of homocysteine (Hyperhomocysteinemia) have been associated with higher incidences of coronary artery disease and increased risk of mortality from cardiovascular diseases. Hyperhomocysteinemia is an independent factor for peripheral vascular, cerebrovascular and coronary heart disease. High homocysteine levels have a variety of injurious effects and are thought to damage blood vessel walls and lead to cardiovascular complications. Impairment in the conversion of homocysteine to cysteine might also lead to higher blood cholesterol levels because cysteine is required for the metabolism of cholesterol. It is also possible that the amino acid affects blood coagulation.

What causes elevated homocysteine levels?

Elevations can arise from genetic defects, or from poor consumption of nutritional factors involved in homocysteine
metabolism, particularly vitamins B12, B6 and folic acid. Insufficient intake of folate, vitamin B12 and B6 are common in
the elderly. However, even young, healthy adults who exercise have been found to have elevated levels of homocysteine.


  • A study of over 1000 people showed that as dietary folate intake decreases, homocysteine level, narrowing of arteries, heart attacks and death due to cardiac disease increase.
  • It is estimated that over 40% of the population is not consuming enough folate to keep homocysteine levels low.
  • Hyperhomocysteinemia is believed to cause 60% of peripheral vascular disease.
  • The Physician’s Health Study showed that men with higher homocysteine levels had a threefold risk of coronary
  • Elevated homocysteine levels lead to structural defects in collagen and may play a role in osteoporosis. In vitro studies
    have demonstrated that homocysteine increases the activity of bone breaking cells, leading to bone resorption.
  • Folic acid supplementation reduces homocysteine levels even if the individual is not folate deficient. Simple supplementation can reduce mild homocysteine elevation in virtually all cases. Folic acid supplementation is more effective than dietary folate at lowering homocysteine levels.

The ingredient combination included in AOR’s MaxMethyl was tested in a randomized, double-blind, controlled study from the University of East London. Participants who took this combination had a significant decrease in their homocysteine levels regardless of their initial levels. Those whose initial levels of homocysteine were high enough to put them in the “at risk” category experienced a dramatic homocysteine drop, indicating that these participants reduced their risk of cardiovascular disease in only 6 weeks of supplementation.

How can homocysteine levels be reduced?

The enzymes that metabolize homocysteine into methionine and cysteine use folate, vitamin B12, and vitamin B6 as cofactors. Trimethylglycine is a methyl group donor and has been shown to reduce plasma homocysteine levels by as much as 30%! Trimethylglycine is the most effective homocysteine lowering substance known. AOR’s MaxMethyl has been formulated to include the cofactors and methyl donors necessary for the methylation of homocysteine into other harmless amino acids, and is therefore an effective supplement for the support of cardiovascular health.

*Prices and product availability are subject to change without notice. All specials and promotions limited to stock on hand.

 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


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